15 Best Anti Aging Wrinkle Creams, Serums, and Products for 2021

This top dermatologist pick from Neutrogena aced the GH Beauty Lab’s anti-aging day cream test. The Good Housekeeping Seal Star quenches dry skin and protects against the sun’s rays with SPF 30. Consumers liked that it absorbed quickly, didn’t irritate (even with retinol) and had little scent. One said, “Hands down, the best wrinkle cream I’ve tried!” GH Lab tests found that it firmed and moisturized, evened tone and could smooth fine lines over time.

Get the ultimate moisture boost with Olay’s cream that outperformed 10 competitors — even a prestige $440 one — in the GH Beauty Lab’s clinical studies. Packed with powerhouse anti-agers including niacinamide and hyaluronic acid, we found the Good Housekeeping Seal Star increased hydration by 50% on average over 24 hours and improved skin texture by 10% in four weeks. For a limited time, you can this for 25% off on Olay’s site. 

This superstar SkinCeuticals serum is proven to perform as a winner of the GH Beauty Lab’s anti-aging serums test. Formulated with niacinamide, it was the best in the test at reducing the look of lines and wrinkles (by 5% over four weeks!). GH consumer testers loved the “almost immediate” fine line improvement and said they were “shocked by the plumpness of my skin the next day.”

RELATED: The 11 Best SkinCeuticals Products of All Time

Not your average serum, No7’s GH Seal star formula ups the game by dispensing the product through a rollerball applicator to massage ingredients like peptides into skin. A clinical study showed visible improvement in firmness and lift of cheeks and jawline over eight weeks of use. Nearly 80% of users found that their skin felt firmer after only one week, according to GH Beauty Lab data analysis.

Great for everyday wear, RoC’s moisturizer was a GH Beauty Lab anti-aging day cream test winner, absorbing quickly and not leaving a greasy feeling on skin. Even better? It has SPF 30 built in — the minimum amount our experts recommend using. In Lab evaluations, the formula reduced visible spots by 4.5% in just four weeks. Consumer testers gave it top marks for softening, firming, and reducing wrinkles.

A worth-it splurge, Lancôme’s luxurious cream with rose extracts, plant oils and vitamins C, E and B5 won the gold in the GH Beauty Lab’s anti-aging eye treatment test for firming and hydrating the eye area. The formula boosted skin firmness by 29% in four weeks and increased hydration by 41%. “My bags are almost gone!” a tester marveled.

RoC’s cream was a winner of the GH Beauty Lab’s anti-aging eye treatments test for tackling every eye-area issue — at a price way below the average. Lab measurements found it increased firmness by 19% and hydration by 20%, reduced wrinkles by 10%, plus brightened dark circles and depuffed undereye bags

Formulated with the antioxidant resveratrol (derived from grapevines) and hydrating hyaluronic acid, this silky Caudalie cream proved to be a powerful hydrator and skin smoother in GH Beauty Lab tests. A Lab anti-aging night cream test winner, it increased skin moisturization by an impressive 43% over six hours and improved skin texture by 12% in four weeks.

A skin-smoothing retinol treatment and a night moisturizer in one, Olay was a winner of the GH Beauty Lab’s anti-aging night cream test thanks to its noticeable brightening, softening, firming and wrinkle-reducing effects at a bargain price. The cream raised skin’s firmness by 27% over four weeks of use per the Lab’s Cutometer machine, which measures skin laxity. 100% of testers agreed it made skin feel softer and they also ranked it best at brightening. “Skin was firmer and smoother each morning,” one noted.

Yes, you should be using an anti-aging neck treatment, too! NeoStrata’s amino acid-infused cream was a winner of the GH Beauty Lab’s anti-aging neck treatments test. It was best at minimizing the look of testers’ neck lines and wrinkles over 12 weeks in standardized digital imaging. “My neck and chest looked smoother,” one reported.

If you want a pick that can do double-duty, this fast-absorbing face and neck serum from No7, a GH Seal star, can’t be beat. The winner in the Beauty Lab’s neck treatment test, it was the best at tightening and lifting skin in Lab evaluations, while also reducing the look of fine lines and wrinkles.

A high-end skincare delivery system now available at the drugstore, these travel-friendly L’Oréal Paris ampoules house concentrated hyaluronic acid, the hydrating ingredient that can bind large amounts of water into skin. In GH Beauty Lab testing, users found that the serum was absorbed fast and their skin was immediately moisturized, softer and refreshed after one use. “My skin looked and felt plump,” a tester remarked. 

Combining botanicals with science-backed skin benefits, like white pine, artichoke and black oat extracts, this creamy GH Seal star Korres serum effectively smooths creases, firms, and minimizes pores. In clinical assessment after four weeks of use, 97% of women showed an improvement in fine lines, wrinkles and firmness, and 100% in the look of pores.

In GH Beauty Lab evaluations, this La Roche-Posay eye cream absorbed quickly, reduced the appearance of fine lines, and diminished under-eye puffiness. It’s packed with powerful anti-aging retinol, so our pros recommend only using this at night before bed, then applying sunscreen every morning. Even with retinol, GH Lab testers didn’t report any irritation. One tester summed it up well, “I didn’t really have much faith in eye creams until trying this one!”

Formulated with powerhouse retinol, Mary Kay’s night cream fights the appearance of fine lines and wrinkles and firms without drying out skin . Even better? The Good Housekeeping Seal Star leaves it feeling hydrated for hours! Like other products with retinol, always wear sunscreen in the morning after using this night cream.